Category Archives: genetics

                                 Want to get pregnant, start by getting healthy

 

If your one of the millions of Canadian couples trying or thinking about conceiving a child, getting pregnant can be one of the most pleasurable and frustrating things in life.

Below you will find suggestions on how to make the process a little easier to achieve for you and your partner.  Although your partner may want to take his time and enjoy each session as an individual and pleasurable experience, we think you’ll find the suggestions will help you through the decision of trying to become a parent easier to deal with.

Shedding the extra pounds that you have worked so hard on adding to your frame is one step on the road to increased fertility.  Quitting smoking increases lung capacity and air flow and increases blood flow to the important parts of the male and female anatomy.  Just as reducing alcohol consumption to less than eight drinks a week and cutting back on caffeine can all help increase a couples chances of conceiving say reproductive endocrinologists and infertility experts.

Here’s the latest research on fertility boosters:

Spread natural peanut butter on the bagel you get at Tim Horton’s.  A Harvard school of public health study determined that women whose lifestyle includes a diet with fewer trans-fats and more mono-unsaturated fats, vegetable proteins, multivitamins and iron were most likely to conceive.  The study also corroborated that being overweight or obese can significantly hamper conception.

Think about the benefits of acupuncture.  Acupuncture raised the likelihood of conception by 65 percent for women undergoing embryo transfer via in vitro fertilization, according to a recent University of Maryland review of seven clinical trials involving 1,366 women.  While this research is preliminary, it’s something to consider as a complement to other healthy fertility choices.  Do research to locate a qualified, well trained acupuncturist who sterilizes his or her needles (to avoid diseases associated with needles, such as hepatitis C and HIV).

Toss a salad.  A small Spanish study found that men who are more fruits and vegetables and fewer meat and dairy products improved their sperm quality and count.  This has been supported by other research that indicates antioxidant-rich produce also has natural benefits that help increase sperm count.

                                                                            Ageless Wonders

  The idea that older works are slower and less productive than their younger competitors is a myth; in fact they often make fewer errors than younger employees.

  Older employees move to slow, forget to do things and are inflexible around the workplace.  They don’t work well in a team atmosphere and can’t adapt quickly to new technologies or changing times.  Many people describe their older colleagues in these terms and these blanket statements are often the reasons personnel managers cite for hiring younger employees over their older competitors.  

  But are these opinions warranted?  Do older workers in truth perform as poorly as their younger counterparts claim?  If so, at what specific functions or tasks do they perform at a lower lever than younger employees?  Neuroscientists and psychologists active in the field of “cognitive gerontology” are currently examining these questions in laboratories around the world.  The answers found to date are eye-popping: although older workers maybe slower at specific jobs or functions, they are actually faster at others and in most cases less prone to reoccurring mistakes.  In fact research shows that only certain brain functions are affected by possible age-related deficits and that basic change in the work environment can compensate for any deficits.

  In the fast pace, shifting, business world of today a lot of importance is placed on the ability to operate at a high rate of speed in the business environment.  And the skill to adapt to changes in the work environment, to be flexible to changing business needs and demands.  Even workers, who for years followed the same routine during their daily jobs, now find the requirements of business have changed and continue to change constantly.  Coping with a constantly shifting environment requires “fluid intelligence”-the focus to switch quickly between different functions, redirect ones attention, and screen out irrelevant or distracting information.

  It has been shown in studies by psychologist Jutta Kray of Saarland University in Germany that older people tend to find difficulty coordinating competing tasks.  She found that individuals over 50, on average, did not do as well on tasks calculated to test an individual’s ability to switch quickly between mental tasks.  For the individual over 50 the studies found the mental effort required for task switching was greater.

  The study wasn’t all bad news for the average 5o-plus Joe or Mary; the old participants did far better after they rehearsed ways to improve their responses.  The scientists concluded that age related performance deficits can be overcome if work environments are constructed in the appropriate way.

  Studies conducted by Michael Falkenstein and Sascha Sommer in collaboration with Juliana Yordanova and Vasil Kolev of the Bulgarian Academy of Sciences in Sofia.  Indicate older subjects take a moment longer to respond to stimulus and yet the results indicate they commit far less mistakes than younger individuals.  Detailed analysis indicates that older people process visual and auditory stimuli just as quickly as younger people did.  Their brains also thought, made decisions and choices as well as their younger counterparts.  The only lag occurred during the final phase-the brain signal that prepares the finger to move.  In older subjects the threshold to initiate a motor response was higher which seems to indicate older subjects operate according to the motto: “Better to be slow but right.”  And numerous other studies over the years seem to indicate this same conclusion.

  For the everyday workplace this has numerous implications as certain jobs require frequent choices, and categorization – for example, any quality control position with a manufacturer.  Since studies indicate the processes of choice and categorization is not significantly affected in older employees, there is no reason to deny them employment in these industries.  Yes the actual motor response is slower in older workers, but this can be an advantage in an industry where a low error rate is the goal.

  Studies indicate older workers make fewer mistakes mainly because they are aren’t as easily distracted from a task.  A surprising finding if you hold to traditional wisdom that older workers are easier to distract from function.  Studies indicate that older workers have a delayed reaction before making a decision, kind of like a mental stop sign to check everything, before proceeding to the next light.  Research has shown that this ability means that older workers commit far less errors, that this slowness gave them a decided advantage in performance.  This check-stop can be very useful for older people in many jobs, such as guiding a car through the busy, constantly moving and changing traffic at the busy intersection.

  While studies do show that our older fellow-humans do not perform as well when under severe time constraints, especially if they must use visual acuity to find a target.  In this situation older employees had longer reaction times and higher error rates then younger competitors.  These situations older workers also found more stressful, but this can be compensated for in the workplace.  Older drivers could be given on board navigation systems to provide the spoken directions instead of a map on a small screen.  Many present workplace situations could be altered in small ways to provide the older employee with the ability to complete the tasks they are better suited to.

  Since older employees have tasks and functions they perform better than their younger competitors, it is wrong to categorize older people as on the whole less valuable in the workplace.  And any small differences can certainly be compensated for by small adjustments in workplace environment and attitude toward older employees.  In the coming years with additional studies and understanding we will be able to isolate the causes of poor performance and redesign the work environment to mitigate these causes.

  Additionally it should be noted that in the real business world, speed and accuracy are not the only criteria determining success.  The older employee has spent years collecting experience and knowledge about the world and business, the younger employee has not gained yet.  Older workers are generally more socially competent, making them more suited for customer relations.

  Furthermore, even though an older worker might be initially slower at a certain mental task, neural networks have been shown to rewire themselves given the opportunity.  For example, cognitive neuroscience professor Roberto Cabeza of Duke University has shown that older people who performed poorly on a memory test activate the same memory areas of the human brain as their younger competitors, yet seniors who did well had a different activation pattern.  Scientists say these results make it clear that neuronal restructuring can help compensate for deficits – although not every older brain is capable of carrying this out.

  With the employment crush in the workplace in recent years and the call to bring older workers back into the workplace to compensate for the lack of workers.  A restructuring of workplaces and brain networks will be necessary if older workers are to be the solution to the problems of the labour market.  The call to rise retirement ages is part of this crush; low birth rates mean fewer people entering the workforce and a need for more skilled, experienced, workers.  Personnel managers equating the age 45 with “over the hill” in coming years will be ignoring a prime source of needed skill and experience if they continue to listen to the assumptions.  Something tells me the over-the-hill-gang, of which apparently I quality for, will be having a thing or two to say about this, because I for one have a lot left to learn, give and teach my fellow human.

 

Man-to-Man: On growing old

 

My subconscious recently approached my conscious mind about writing an article explaining the difference between life now and the way life was back in my younger days. My conscious mind enquired about what exactly it was referring to?

“Well it’s hard to go wrong in a men’s magazine if you talk about sex, power and money.” Said my subconscious.

So, let’s begin with sex. My better half staunchly refuses me sex with any of the semi-clad, twenty-something, women working at my publisher’s office. When I point to her that it will only take a second, that the girls will hardly notice, that it will mean nothing to me at all, and that the doctor did say that sexual activity of any kind is good for a man my age, she throws me a look Napoleon gave Russia. I pretended I was joking. But now you know where the reigns of power rest and the money too. We have a lifetime deal; fifty-fifty right down the middle. I earn it; she spends it. Owe, we do love each other fiercely. Whatever her name is?

My power like my body shows signs of dissipating. Now when I look into the mirror, I realise I will need my glasses… I still have healthy teeth, but sadly they are Chinese teeth — like Canadian politicians they are crooked and stained from use, going in all directions at once. My mind? Well it received a summons to appear in court last month, but forgot the post-it-note it pinned to the refrigerator. It forgets how to pronounce words at times — preferring to say them backwards. At times my mind seems to have Alzheimer-like symptoms, where it refuses to see objects in front of my face. My glasses, my coffee, my cat’s, my wife all seem to disappear as soon as I’m looking for them. Personally I prefer book-lag, the exhaustion a writer feels after a successful book launching. Sometimes visualising the object in my mind helps my nose lead me to the object of my desire. I follow the aroma of my coffee, my mistress’s fragrant perfume, and the cat’s you can smell from across town.

Don’t let me fool you. Aging isn’t funny. I still feel sixteen, but every time I start thinking so the bedroom light comes on and this ugly old man jumps out of the wall mirror at me. In fact I recommend never getting old. Forget all the advertisements telling you to invest your money for your retirement — stay young forever. Not frantically fumbling to remember the name of the woman you have lived with for centuries.

So gentlemen, I have to go now. There are a couple nice men in white coats holding a large needle and accompanying jacket out to me. Perhaps its time to sit on a balcony over looking a slowly meandering stream, maybe its time for my Viagra… If things persist I’m going to kill my f…king doctor.

One or two final points: Don’t play golf it will prematurely age you. Turn off the squawk box; they’ll only try to convince you your getting old. Can people who look that good really be trusted? Just keep forgetting everybody’s name and complaining about everything. Since these two treasures are one of the few pleasures of getting old.

 

Warren Hayashi

 

Deadly Accurate Cancer Killers

 

Small carbon missiles target cancer and signal the beginning of the end for chemo’s uncomfortable side effects.

The negative side of conventional cancer killing techniques like chemotherapy is the destruction of surrounding non-cancerous cells during the course of the treatment regiment, triggering nausea, rashes, and hair loss.

The Cure is to eliminate cancerous cells while leaving adjacent non-cancerous cells untouched. The answer depends on hollow orbs of carbon polymer each 1,000 times smaller than the head of a pin. Omid Farokhzad of Harvard University and Robert Langer of the Massachusetts Institute of Technology are inserting small amounts of chemotherapy drugs into these orbs, known as nanoshells

It’s important that the orbs only contact the cancerous cells; to make this possible the scientists impregnate the outer surface with filaments of molecules, referred to as aptamers, which attach only to proteins that grow from cancerous growths. Acting like the GPS in your cell phone, aptamers Sheppard the transfer of the particles to the cancerous cells. Arriving at the surface of the cancerous cell at a specified place, aptamers offload their anti-cancer payload inside the suspect cells, eliminating them in the process – without destroying healthy cells during the treatment.

Ready for battle? We can expect these precision-guided cancer killers sometime within the next decade say Langer and Farokhzad. Langer and Farokhzad published research this year indicating that their nano-orbs eliminate tumours in mice, but point out that three years of animal studies are needed to authenticate their research. Additional testing of human subjects will take up to five years or more. They say the wait will be worth it – associate researchers think the left-right combination of nano-particles and aptamers will be the future of medicines final victory over cancer.

Bonus research? Langer and Farokhzads’s research has spin-offs in the area of heart-disease detection. Shelby Caruthers of Washington University in St. Louis has outfitted their nano-spheres with gadolinium atoms. Inserted into the body, the nano-particles group around arterial plaques – a hallmark of cardiovascular disease – and signal while undergoing an MRI scan, pinpointing the area for treatment.

 

Warren Hayashi